2001 Mar 30;276(13):9770-4. doi: 10.1074/jbc.M010092200. Three unique prosthetic groups are found in cytochrome b 6 f: chlorophyll a, β-carotene, and heme c n (also known as heme x). Please enable it to take advantage of the complete set of features! Its goal is to discover data sets across data repositories or data aggregators. J Bioenerg Biomembr. Zito F, Finazzi G, Delosme R, Nitschke W, Picot D, Wollman FA. Epub 2014 Aug 20. Single amino acid substitutions in cytochrome b (6) at the positions D148, A154, and S159 revealed altered binding of the quinol-oxidation inhibitors 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone (DBMIB), myxothiazol, and stigmatellin. Single amino acid substitutions in cytochrome b(6) at the positions D148, A154, and S159 revealed altered binding of the quinol-oxidation inhibitors 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone (DBMIB), myxothiazol, and stigmatellin. The Cytochrome bc (1) Complex and its Homologue the b (6) f Complex: Similarities and Differences. NIH Intraprotein transfer of the quinone analogue inhibitor 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone in the cytochrome b6f complex. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Induction events and short-term regulation of electron transport in chloroplasts: an overview. Biochemistry. Epub 2017 Oct 24. Korosh TC, Dutcher A, Pfleger BF, McMahon KD. 2017 Nov 7;114(45):12063-12068. doi: 10.1073/pnas.1713343114. Photosynth Res. J Exp Bot. From the ‡ Centro di Studio del C.N.R. Biochemistry 2004 , 43 (24) , 7707-7716. Cytochrome P450 Inducers. doi: 10.1128/mSphere.00538-17. Ferredoxin-plastoquinone reductase (FQR) activity during cyclic electron flow (CEF) was first ascribed to the cytochrome b 6 f complex ( b 6 f ). USA.gov. The Qo site of cytochrome b6f complexes controls the activation of the LHCII kinase. Clipboard, Search History, and several other advanced features are temporarily unavailable. The inter-monomer space within the core of the cytochrome b6f complex dimer is occupied by lipids, which provides directionality to heme-heme electron transfer through modulation of the intra-protein dielectric environment. Other inhibitors of cytochrome c oxidase will not be discussed here, but are important biologically, such as sulfide, formate, and nitric oxide. Nelson ME, Finazzi G, Wang QJ, Middleton-Zarka KA, Whitmarsh J, Kallas T. J Biol Chem. 1999 Jun 1;18(11):2961-9. doi: 10.1093/emboj/18.11.2961. A proposed pathway of proton translocation through the bc complexes of mitochondria and chloroplasts.  |  mSphere. Some have been commercialized as fungicides (the strobilurin derivatives, best known of which is azoxystrobin ; QoI inhibitors) and as anti-malaria agents ( atovaquone ). 2018 Feb 28;3(1):e00538-17. Cytochrome Important Links: An excellent review of the Respiratory Chain. 2019 Apr;31(4):911-931. doi: 10.1105/tpc.18.00916. Using the cyanobacterium Synechococcus sp. 2006 Jan 3;103(1):69-74. doi: 10.1073/pnas.0504909102. 2004;79(1):25-44. doi: 10.1023/B:PRES.0000011926.47778.4e. NIH Would you like email updates of new search results? The analysis of fluorescence induction at room temperature indicates that stigmatellin consistently prevented transition to State 2, whereas 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone behaved as an inhibitor of state transitions only after the cells were preilluminated. sulla Biologia Cellulare e Molecolare delle Piante, The cytochrome b 6 f complex is a dimeric protein complex that is of central importance for photosynthesis to carry out light driven electron and proton transfer in chloroplasts. Cytochrome b6 arginine 214 of Synechococcus sp. A native structure of the cytochrome b 6 f complex with improved resolution was obtained from crystals of the complex grown in the presence of divalent cadmium. NLM The cytochrome bf complex, which links electron transfer from photosystem II to photosystem I in oxygenic photosynthesis, has not been amenable to site-directed mutagenesis in cyanobacteria. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 1993 Jun;25(3):233-44. doi: 10.1007/BF00762585. The central role of the green alga Chlamydomonas reinhardtii in revealing the mechanism of state transitions.  |  Cytochrome P450 inhibitors inhibit the ability of the human body to break down certain substances, potentially increasing the amount of time a substance is active in the body.. Cytochrome P450 enzymes are essential for the metabolism of many medications. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Epub 2015 Oct 27. As much as two-thirds of the proton gradient used for transmembrane free energy storage in oxygenic photosynthesis is generated by the cytochrome b 6 f complex. Photosynth Res. Epub 2019 Mar 8. Light-Harvesting Complex Stress-Related Proteins Catalyze Excess Energy Dissipation in Both Photosystems of Physcomitrella patens. Quinol oxidation on the electrochemically positive (p) interface of the complex occurs at the end of a narrow quinol/quinone entry/exit Qp portal, 11 Å long in bc complexes. Cytochrome b 6 f receives electrons from plastoquinone and delivers them to plastocyanin. Previously [Roberts, A. G., and Kramer, D. M. (2001) Biochemistry 40, 13407−13412], we showed that 2 equiv of the quinone analogue 2,5-dibromo-3-methyl-6-isopropylbenzoquinone (DBMIB) could occupy the Qo site of the cytochrome (cyt) b6f complex simultaneously. The inhibitor DBMIB provides insight into the functional architecture of the Qo site in the cytochrome b6f complex. NLM Ascorbate-mediated LHCII protein phosphorylation--LHCII kinase regulation in light and in darkness. The cytochrome b 6 f complex is one of three hetero-oligomeric intramembrane protein complexes in the electron transport pathway of oxygenic photosynthesis in plants, algae, and cyanobacteria that can be separated and purified from the respective membrane source. Cytochrome bf and mitochondrial-type cytochrome bc(1) complexes are closely related in structure and function but exhibit quite different inhibitor specificities. Modulating energy arriving at photochemical reaction centers: orange carotenoid protein-related photoprotection and state transitions. 2010 Dec;1797(12):1858-68. doi: 10.1016/j.bbabio.2010.07.008. Contrasted effects of inhibitors of cytochrome b6f complex on state transitions in Chlamydomonas reinhardtii: the role of Qo site occupancy in LHCII kinase activation J Biol Chem . USA.gov. Would you like email updates of new search results? As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. Epub 2005 Jan 4. Monogalactosyldiacylglycerol deficiency in tobacco inhibits the cytochrome b6f-mediated intersystem electron transport process and affects the photostability of the photosystem II apparatus.  |  2004 Oct 22;279(43):44621-7. doi: 10.1074/jbc.M406955200.  |  DOI: 10.1021/bi049521f. This site needs JavaScript to work properly. * Giovanni Finazzi ‡**, Francesca Zito§, Romina Paola Barbagallo and Francis-André Wollman ¶. However, this was later dismissed since b 6 f inhibition by antimycin-A (AA) could not be reproduced. 6 ) subunit of the cytochrome bf and mitochondrial-type cytochrome bc ( 1 ) complexes are closely related in and... ) is the most abundant lipid component of the Qo site of cytochrome P450 inhibitors the bc of. Hasan SS, Cramer WA the complete set of features ; 43 ( 24 ), MK. 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